Yoshida sends a long ball downfield, which Cedric collects - but Walker forces him out for a Spurs throw. Tottenham are headed for a win - but Southampton have given a great account of themselves in defeat too.
90' +4
Oriol Romeu gets yellow.
Bertrand's break down the left is pinched by Wanyama, to break up another Southampton attack - and then Romeu is booked too as he clatters Janssen.
90' +2
Romeu puts a long one down the left flank towards the box for Long once more - and he is caught offside for the fifth time today. He's still not happy.
90' +1
Close for Southampton! Boufal lets loose with a left-footed curler from the right - it spins off too far though, and doesn't seriously trouble Lloris. Saints still pushing.
90'
Wasted chance for Spurs! Janssen shoots from the left when he should have crossed to Alli in the box and his teammate isn't happy. Tottenham should have put the game to bed there. Five added minutes.
88'
Rodriguez gets into open space to the right of the box for Saints - but Alderweireld is quick to block. Southampton still seeking the goal that will give them a point.
86'
V. Janssen enters the game and replaces C. Eriksen.
Goalscorer Eriksen makes way for Vincent Janssen as Spurs use their third substitute.
85'
Winks and Trippier are at it again, creating a perky double-act of interplay to get Spurs some strong field position. Saints aren't lying down though - as Cedric earns a throw-in on the right for the visitors.
83'
Tottenham can't make anything of their increased spell of pressure, through Winks and Trippier - and Saints make them pay with some great counter-attacking football that ultimately goes out for a Lloris goal-kick.
81'
S. Boufal gets yellow.
A yellow card for Sofiane Boufal now, after he came together - violently - with Winks. Spurs get a free kick.
Minute
Description
80'
J. Rodríguez enters the game and replaces N. Redmond.
Ten minutes left on the clock and Southampton are still showing spirit here, seeking their second goal to draw level. Redmond is their final change, being replaced by Jay Rodriguez.
78'
K. Trippier enters the game and replaces K. Walker.
Kyle Walker is off - with a thumb injury it seems - and Kieran Trippier is the man to replace him.
77'
Winks is immediately clipped down by Davis on a quick run - and earns a free-kick for Spurs in a good position. Eriksen's shot is too long however and flies out by the right post.
75'
H. Winks enters the game and replaces Son Heung-Min.
Son has worked hard in the place of Kane today - but he now gives way for Harry Winks.
74'
Ward-Prowse and Cedric create some great interplay on the right but Long is then called for offside once more. He's not happy with the decision and remonstrates with the linesman.
71'
Son gets the ball on the right flank, but puts it out himself so that the game is stopped for Eric Dier, who lies crumpled on the turf. One of seven players on the pitch today called up to the England squad, he slowly regains his feet and is helped to the edge of the field for the time being.
69'
S. Boufal enters the game and replaces D. Tadić.
Indeed, it is Tadic who departs with Sofiane Boufal on in his place.
68'
Walker flicks it around to Dembele in midfield, but Southampton don't let them advance. Meanwhile, the visitors are looking to make a change - but who? Tadic, perhaps?
66'
Spurs are undefeated at home in the league this season - since Southampton last visited White Hart Lane, in fact. They are looking increasingly fragile around midfield however; Saints have got the mental advantage despite being behind.
64'
A great ding-dong tussle going on at the edges between Bertrand and Walker today, with the Spurs man earning a free-kick in their latest entanglement. Lloris takes, but Saints close up ranks quickly.
62'
From the free-kick, Ward-Prowse tries to find Long - but the weight behind the ball is too much and it skims out of play.
61'
V. Wanyama gets yellow.
Romeu flicks onto Tadic, who goes down - softly - to Wanyama. The Spurs man is booked for his foul - and Tadic, who has hit the ground a few times today, seems to be still carrying a knock.
59'
Dembele puts a square ball to Eriksen, who flicks it back on the angle to fox Southampton's defence, before it falls to Son. He runs out of space on the left side however and Saints get a goal kick.
57'
Long is caught offside as he mistimes is run down the left. He's brought an energy to proceedings since he came on though - and he shows it with a great shot a moment later from the right, stopped well by Lloris.
54'
And just like that, Saints are right back in this game. Spurs look rather shellshocked and Ward-Prowse pushes for a second, only to be unable to get his shot away. Top stuff from the visitors.
52'
J. Ward-Prowse has scored a goal for Southampton! Assist by R. Bertrand.
Fun fact; Dele Alli's goal earlier on was his first penalty in a senior game. In previous spells at MK Dons, and with Spurs, he had never taken one until today.
Assist Ryan Bertrand
SOUTHAMPTON ARE IN THROUGH WARD-PROWSE! Bertrand takes the ball on a run down the left flank before looping it across to the former England junior who beats Lloris to tuck it in the bottom right corner.
50'
Close for Eriksen once more! Son feeds him in centre midfield and he plays down towards Walker. The England man flicks it back inside and the Dane's shot skirts over the bar.
48'
Eriksen loops it out to Davies on the left, but his cross back into the box finds only Bertrand and Saints clear with ease.
46'
And we're back underway at White Hart Lane. No changes from either team at half-time - just the one in that first half, with Long on for the injured Gabbiadini. Cedric takes the ball down the right for Saints but ultimately takes it out for a Spurs goal kick.
45' +2
Redmond earns a free-kick in a dangerous position for Spurs. Can Southampton get on the scoresheet before half-time? Ward-Prowse to take.
Ward-Prowse plays it across to the edge of the box and Cedric lets loose with a volley that requires a leap from Lloris. Tadic is brought down in the box seeking the rebound - and appears genuinely injured. Davies has got away without conceding a penalty for his challenge on the Saints man.
45'
Son flicks it back to Eriksen, who pushes it back to the Spurs line before a long ball seeks out Davies on the left flank, only for him to be unable to reach it in time. Three minutes added to the end of the half here.
43'
Dier has a free-kick that seeks out Walker - but he comes together with Yoshida and concedes one of his own. Forster pumps it down field for Bertrand and Redmond but the Saints pair can't make anything of it.
41'
Son and Vertonghen have some great interplay going forward, before pushing it out to Eriksen on the left. He curls a clever pass across the box to the lurking Korean forward - but he just can't get there in time to head the ball in. Close for Spurs.
39'
K. Walker gets yellow.
Cedric loses it to Son on the left flank, but his wayward pass falls to Bertrand instead. Walker is then booked after coming together in a clumsy fashion.
37'
Spurs of course are still very much in the search for the title, if Chelsea were to hit a rough patch. They certainly look like a champion side this afternoon - two calm finishes for the home side so far, to pile the pressure on Southampton.
35'
Saints are back to eleven men now, with Long able to join the fray. He reads a cross on the right flank well and earns his team a throw-in too.
33'
Penalty goal scored by D. Alli for Tottenham Hotspur!
ALLI SCORES! It's a cool right-footed strike that foxes Forster and sends him to the right as the Spurs man buries it in the bottom left corner. 2-0 to Tottenham.
32'
S. Long enters the game and replaces M. Gabbiadini.
PENALTY FOR SPURS! Alli goes down as he is clipped by Davis on the edge of the box - and the Tottenham man will now take the kick. Here we go...
30'
Bad news for Southampton - Gabbiadini has been pulled up with a groin injury and is accompanied from the field by the physio. Not a sight Saints fans will have wanted - and it's Shane Long who will replace him, although he's not yet on the pitch due to Spurs restarting play.
29'
Another close chance for the visitors - Tadic in front of goal absolutely skies it. His blushes are spared somewhat by the fact that Redmond was already offside.
28'
GABBIADINI BRUSHES THE NET! Saints' star striker feeds Tadic on the edge of the box, who plays a square pass back - and the ex-Napoli player's shot skirts the edge of the net.
26'
N. Redmond gets yellow.
Gabbiadini floats a long pass across to Redmond on the left - but the Saints man gets a yellow card after coming together with a Spurs man. He holds his hand up and acknowledges the blame with a rueful grin.
23'
ERIKSEN GOES CLOSE AGAIN! The goalscorer puts a shot in from the box, but it bounces off the legs of Davis. From the corner, Alderweireld hacks it towards goal and only the reflexes of Fraser Forster denies Spurs a second.
21'
Vertonghen's attempted pass to the box for Eriksen finds only Ward-Prowse, but he forces it out for a corner. Alli gets it from a set-piece but he can't turn it in either and Saints hack the ball out of danger.
20'
The visitors are starting to hold a bit more shape now, and earn a throw on their right flank. Gabbiadini is the man who gets the ball, but Alderweireld manages to get it away from the danger man.
17'
Close for Southampton! Romeu turns a wonderful ball around for a right footer just on the side of the Spurs box - and had it not been for a nick off one of his teammates, it probably would have nestled in the top corner. A bit of verve from Saints, all of a sudden.
16'
Saints look rattled, and no wonder. Even with the pressure Spurs have piled on them so far, it felt like a goal out of nowhere. Yoshida feeds it across to Cedric, who puts a flat pass down to Ward-Prowse - but Tottenham force it out for a throw.
14'
C. Eriksen has scored a goal for Tottenham Hotspur! Assist by M. Dembélé.
WHAT AN OUTRAGEOUS SHOT! Christian Eriksen breaks the deadlock with a beautiful left-footer just outside the middle of the box. Dembele feeds him on and it's a peach of a shot. Spurs lead 1-0.
13'
Walker tries to turn a cross into the box but Yoshida forces it out for a corner. From this, Son very nearly connects with a looping header - and goes down in the box too. No penalty given.
11'
E. Dier gets yellow.
A booking for Dier as he clips down Redmond with a clumsy challenge featuring foot and knee. The pair will be in the mix for England next week - though there are no loyalties here, obviously.
10'
Alli feeds Eriksen, down centre field, but the Spurs man is unable to turn it into anything. Davies goes close down the left too, but he is turned around by Cedric and Saints push the home side back down field.
8'
Davis flicks it back to Romeu, who clips it onto the recovered Tadic. He slips it through for Gabbiadini who is fast to close onto it - too fast in fact, as he is called for offside as he enters the Spurs box.
6'
A stoppage in play now - as Cedric earns a throw for Southampton - as Dusan Tadic goes down clutching his head. He thankfully seems alright but it kills any momentum Saints were creating too.
4'
Chance for Tottenham! Eriksen feeds Son superbly heading into the box, and only Forster's fast hands deny the Spurs forward a goal. Ali goes close from the following corner but he is unable to drill it past the defence.
2'
Dier floats a long cross over from the right flank, seeking out Eriksen but Stephens is quick to defuse any potential danger. Tottenham already look up for it; Saints look a touch rusty and sluggish.
1'
And we're off! Southampton's Redmond gets us underway and the game is on at White Hart Lane.
Both teams are looking to make it three wins on the bounce in the top flight this afternoon, with Tottenham having posted victories over Stoke and Everton, and the Saints taking the scalps of Sunderland and Watford. Southampton’s EFL Cup final defeat to Manchester United is still fresh in the memory though; could that still be on their mind today?
So begins life after Kane once more for Tottenham Hotspur. Their talismanic striker left White Hart Lane on crutches last week after they thumped Millwall in the FA Cup. Will they be able to keep a hold on their automatic Champions League place without their star man? Or will Southampton put a dent in their ambitions by snatching a win? Good afternoon ladies and gentlemen, and welcome to the Premier League.
It’s Christian Eriksen who comes into side in place of the injured Harry Kane for Spurs then, with Son Heung-min promoted to the frontline as the lone centre forward. Southampton meanwhile keep faith with the team who ran out victors last week – and they’ve got on the scoresheet eight times between their previous two games. Are we expecting goals galore in North London today?
It hasn’t been plain sailing for Claude Puel’s outfit this year either, with their EFL Cup final appearance the highlight of a campaign that has seen them fail to match the impressive, Europa League-qualifying form of last year. Puel has been in the job for less than a year – but he will be hoping for a strong run-in to signify chances for next season.
Though Spurs have a Kane-shaped void to fill as their goal machine, Saints have their new top cat still firing on all cylinders; Manolo Gabbiadini has posted six goals in his four appearances since signing from Napoli in the January transfer window. Could he be the key to a potential upset this afternoon, frustrating Mauricio Pochettino’s men in their ambitions?
For a while, it looked to be all one-way traffic in that first half. Tottenham started with a spark Southampton didn't have, and Christian Eriksen made them pay with a superb shot. Then, as their star man Manolo Gabbiadini was helped from the field with a groin injury, Saints conceded a penalty too, one which Dele Alli slotted home. The visitors went close a few times in the final minutes - but at the break, they remain without a goal. Tottenham 2-0 Southampton the score.
Ten wns in a row for Tottenham in their final season at White Hart Lane it is! They overcome the absence of Harry Kane to cling on for three points against a gutsy, spirited Saints performance, sparked by a James Ward-Prowse goal early in the second half. Defeat for Claude Puel then; victory for Mauricio Pochettino. Final score in North London; Tottenham 2-1 Southampton.
Three points is three points in the end - and Spurs will be glad to wrap it up. They travel to Burnley in a fortnight after the international break, as they keep up their pursuit of Chelsea. Southampton meanwhile host Bournemouth in two weeks - and they'll be hoping an injury to Manalo Gabbiadini is not as serious as it seems. Football - there's nothing quite like it. Thank you for the company and have a good evening!
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